Ultra-sensitive and re-usable graphene-modified double inter-digitated capacitive (DIDC) sensing chip to detect SARS-CoV-2 virus at femtomolar level
RFIC Bio Center, Kwangwoon University, Seoul, South Korea, South Korea
Diagnostic technologies for identification of SARS-CoV-2 from human nasal, buccal, or saliva samples
Tech Brief: This technique, for the first time, proposes a re-usable capacitive immunosensor fabricated using a graphene oxide-modified double inter-digitated capacitive (GrO-DIDC) chip for the detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at femtomolar (fM) level selectively and withing 3 second.
FIGURES OF MERIT Value Proposition: In spite of outstanding performance of RT-PCR , the need of a expertise (to prepare sampling) based time consuming (16 to 22 hours) process depend on sophisticate instrumentation limits applicability of RT-PCR to manage a pandemic. This raised the demand of making diagnostics systems speedy, cost-effective, sensitive, selective, easy to operate, need of low volume sampling, suitable for bioinformatics collection, easy bioinformatics analysis such as 0.1 femtomolar (fM) LoD, suitable to explore infection progression, and faster therapy decision. Our research outcomes project a selective rapid detection of SARS-CoV-2 antigen selectively using a re-usable capacitive SARS-CoV-2-Ab-EDC-NHS-GrO-Ti/Pt-Glass-DIDCs sensor which can be transformed into a portable analytical tool with scaled up capability to perform point-of-care application to manage COVID-19 pandemic outbreak, even in personalized manner.