E. T. Chen, J. T. Thornton, S-H Duh, P. T. Kissinger, K. Bowen
Advanced Biomimetic Sensors, Inc., Maryland, United States
Keywords: Nanobiomimetic Quantum sensing, Reagent-free, Biomimetic organ on a chip, Mild traumatic brain injury (mTBI), flexible Josephson junction arrays
In wartime operations, the Department of Defense prioritizes rapid detection and intervention to save warfighter lives, preserve cognitive function, and maintain combat readiness—particularly for mild traumatic brain injury (mTBI) and physiological stress, which are often invisible yet mission-critical threats. Pioneer QSensing® delivers a breakthrough portable, self-detectable platform that integrates quantum sensing with a nanostructured biomimetic enzymatic membrane and flexible tunable Josephson junction (FTJJ) array. This enables label-free, reagent-free detection of a broad biomarker panel—including elevated beta-amyloid (a hallmark of mTBI neuronal damage), glucose, acetylcholine (ACH), N-acetylcysteine (NAC), acetyl-CoA, ATP, pyruvate, MMP-2, cysteine, and others—via unique Josephson nonlinear anharmonic oscillation frequency fingerprints. Operating at room temperature with no refrigeration or bulky equipment, the device monitors open-circuit potential energy balance and protein refolding imbalances in under one minute. It provides real-time, interference-free results with 98–100% recovery rates and NIST-traceable accuracy under tracer-free conditions. By delivering instant, actionable intelligence on energy stress and mTBI indicators directly at the point of injury, QSensing® empowers medics and commanders to make life-saving decisions faster, reduce long-term disability, and sustain warfighter performance in austere, contested environments.