G. Gao and G. Travish
ViBo Health, California, United States
Keywords: MRS, NMR, Medical Devices
Trauma remains a significant public health concern, leading to high mortality rates in both civilian and military sectors, resulting in substantial years of life lost. Long-term post-traumatic effects, varying in severity among individuals, impose significant personal and economic burdens. To address these challenges, understanding trauma recovery at an individual level is imperative. Biomarkers such as Hemoglobin (Hb), creatinine, hematocrit, blood sugar, and urea are associated with trauma, while traumatic brain injury (TBI) biomarkers include GFAP, UCH-L1, and S100B. Magnetic Resonance Spectroscopy (MRS)-based techniques enable the measurement of these markers, alongside metabolites and drugs like morphine. Our research focuses on Pyruvate & Global Arginine Bioavailability Ratio (GABR) as indicators of trauma recovery. To facilitate individualized trauma monitoring, we are developing a non-invasive, portable diagnostic device using Magnetic Resonance Spectroscopy (MRS) technology. This innovation deploys MRS in an low-power, low-volume, low-weight, and low-complexity casualty health scanner. Our study outlines the device, presents initial laboratory results, including bias and probe system characterization, and discusses its potential application in resource-limited settings.