S. Chien, H. Sarojini, G.J Kotwal
NOVERATECH, LLC, Kentucky, United States
Poster stand number: W122
Keywords: Battlefield trauma, wound healing, intracellular ATP delivery, rapid tissue regeneration, ischemiaCombat casualties have been a significant medical challenge for the US Arm without effective treatment. The signature wound in modern war is the blast injury, and nearly 90% of combat-related deaths occur before the wounded arrive at combat field hospitals. Management is extremely challenging because the damage caused by firearms is deep, extensive, and often accompanied by burns and contamination. This early time falls exactly within the traditional 3-6 days of “lag phase” in wound healing during which no new tissue is regenerated no one has ever been able to change it. For the first time in history, we have found an approach that may change the current dogma. We have developed a technique for intracellular ATP delivery (ATP-vesicles). When we use ATP-vesicles for wound healing, granulation tissue starts to appear within 24 hours. It keeps growing and fills the wound cavity within a few days (Fig. 1). None of the control dressings have such effects. A preliminary mechanistic study has shown that the extremely rapid tissue regeneration is the result of very early, rapid, and massive macrophage accumulation, in situ proliferation, M2 polarization, and direct collagen production, long before traditional fibroblasts come into play.