A palm-size, wireless, low-cost nanosystem for real-time sensing viruses, bacteria, cancers, and screening drugs, vaccines, and antibodies

R. Tian
University of Arkansas, Arkansas, United States

Poster stand number: T132

Keywords: Pal-size wireless nanosensor, virus, cancer, stem cell, antibody

The ongoing COVID-19 pandemic demands a new tool for detecting live viral particles simply, affordably, accurately, and quickly, which is a grand challenge to all the technologies in clinical use and products in the market. Here we report a new bio-sensing methodology with 11 new advantages. 1) Directly detecting live (infectious) virus particles. 2) Highly sensitive, able to detect 50 virus particles. 3) Highly specific, with low false-negative and false-positive probabilities. 4) Real-time, as ever detection takes only 3-5 seconds. 5) Needing no other reagents or processes. 6) Small (palm-size). 7) Simple, just mixing the specimens in saline with cells and pipetting them onto the sensor. 8) Wireless, able to connect to a computer or smart cellphone via WiFi for remotely monitoring the detection results. 9) Ultralow-cost, as detecting each sample is ≤$0.05/sample. 10) Scalable, for potentially detecting up to 96 samples simultaneously. 11) Versatile, because it can detect virus particles and virus-neutralizing antibodies, evaluate efficacy of antiviral drugs and vaccines, and detect antiviral antibodies. This highly and quickly manufacturable and marketable all-in-one tool (detecting viruses, antibodies, and antivirals) integrates the technological innovations with the methodological advancements for effectively detecting viruses, bacteria, cancer cells, tumors, stem cells, and screening drugs, vaccines and antibodies.