R. Shekarriz, D. Friedrichsen, B. Brooks, G. Silaski, E. Wiest, and N. Kanagy
Exhalix, LLC, United States
Keywords: Biosensor, wearable, electrocatalysis, health monitoring, nanoparticlesWe report a non-invasive method of detection of small biomolecules for health monitoring. This detection method, known as Transdermal Arterial Gasotransmitter Sensor (TAGS), uses a nanoparticle gold electrocatalyst to quantify trace levels (parts-per-billion) of endogenous biomolecules such as hydrogen sulfide that permeate through the dermal layer of human subjects. Hydrogen sulfide for example has been identified with peripheral artery disease and small vessel disease, conditions that result in poor microvascular perfusion and ischemia in diabetic patients and elderly. Other small biomolecules of interest are acetaldehyde, formaldehyde, acetone, ammonia, and isoprene, which can be simultaneously detected for signature recognition and specific detection of abnormal chronic and acute health conditions. This presentation will provide technical details of the sensing methodology, validation results from animal and human studies, and vision of the wearable product.