N.A. Sopko, I.V. Estabrooke, M.A. Marano, G.S. Mundinger, D.J. Smith, J.L. Partridge, K.A. Churukian, M.S. Granick
PolarityTE, Utah, United States
Keywords: Autologous homologous skin construct, wound healing, burn injuries, acute trauma, necrotizing fasciitisCutaneous wounds are a significant military healthcare burden. The major wound etiologies include burn, infectious, and traumatic. They can be further complicated by necrotizing fasciitis, which is associated with a 30% mortality rate. Large wounds are often treated with split-thickness skin grafts (STSGs), which lack the function of normal skin, are cosmetically conspicuous, and can undergo donor-site morbidity. An autologous homologous skin construct (AHSC), SkinTE™, is a commercially available FDA-registered therapy that regenerates full-thickness skin and associated appendages from a small full-thickness harvest. Four burn wounds, three avulsion crush injuries and a case of necrotizing fasciitis left 8 patients with large, open wounds with exposed deep structures. The wounds were treated with a single application of AHSC and the donor sites were closed primarily. AHSC was evaluated for its ease of use, donor site morbidity, and ability to close complex wounds with full-thickness skin. AHSC was effective by completely closing acute burn and traumatic wounds including an infectious disease case, and demonstrated regeneration of full-thickness skin with dermal appendages similar to native skin. In sum, AHSC is an efficacious therapy to heal cutaneous defects akin to combat and non-combat military injuries that can be utilized in low resource settings.