Novel therapy for complete regeneration of functional skin in burn injuries, acute trauma and infectious disease

N.A. Sopko, I.V. Estabrooke, M.A. Marano, G.S. Mundinger, D.J. Smith, J.L. Partridge, K.A. Churukian, M.S. Granick
PolarityTE, Utah, United States

Keywords: Autologous homologous skin construct, wound healing, burn injuries, acute trauma, necrotizing fasciitis

Cutaneous wounds are a significant military healthcare burden. The major wound etiologies include burn, infectious, and traumatic. They can be further complicated by necrotizing fasciitis, which is associated with a 30% mortality rate. Large wounds are often treated with split-thickness skin grafts (STSGs), which lack the function of normal skin, are cosmetically conspicuous, and can undergo donor-site morbidity. An autologous homologous skin construct (AHSC), SkinTEā„¢, is a commercially available FDA-registered therapy that regenerates full-thickness skin and associated appendages from a small full-thickness harvest. Four burn wounds, three avulsion crush injuries and a case of necrotizing fasciitis left 8 patients with large, open wounds with exposed deep structures. The wounds were treated with a single application of AHSC and the donor sites were closed primarily. AHSC was evaluated for its ease of use, donor site morbidity, and ability to close complex wounds with full-thickness skin. AHSC was effective by completely closing acute burn and traumatic wounds including an infectious disease case, and demonstrated regeneration of full-thickness skin with dermal appendages similar to native skin. In sum, AHSC is an efficacious therapy to heal cutaneous defects akin to combat and non-combat military injuries that can be utilized in low resource settings.